This article explores pigmented conjunctival lesions, emphasizing their clinical and histopathologic features. It highlights the diagnostic challenges posed by the overlapping clinical morphologies of benign, premalignant, and malignant melanocytic proliferations; biopsies of such lesions may be evaluated by dermatopathologists. This review discusses the distinct origins and molecular genetics of conjunctival melanocytic neoplasms, especially in sun-exposed areas like the bulbar conjunctiva, which share similarities with their cutaneous counterparts. Uveal melanoma, which is not the topic of this paper, is completely distinct molecular genetically and biologically. Understanding terminology used by ophthalmologists allows for more accurate communication regarding the managment and prognosis of patients with ocular melanocytic tumors.
Publication date: 2026-02-06
PMID: 41651613
Source: PubMed